PhD (University of Glasgow)
Research Areas: Medical Pharmacology, Cell Biology, Biotechnology
Research in Sweeney Lab:
Our research focus is on cardiometabolic diseases. Thus, understanding mechanisms underlying diabetes or heart failure is a major interest. Research in our lab is funded by CIHR, NSERC, IDRC, Heart & Stroke Foundation and Thalassemia Foundation of Canada.
Our collaborative network includes research groups across Canada as well as in Hong Kong, Thailand, South Korea and United Kingdom. Our work may aid the development of therapeutic strategies for the treatment of cardiometabolic diseases in obesity. Indeed, we have close partnership with a pharmaceutical company from USA to aid in the development of adiponectin-based therapeutics.
Information for Prospective Graduate Students
Our lab is open for both PhD. and MSc. students. We look for potential graduate students who have related research experience and demonstrated skills, a strong academic record, are creative and highly motivated, and whose interests match on-going work in the lab. Prospective students may provide a statement of your interests, a CV and (unofficial) transcript. Letters of recommendation will be requested prior to acceptance for graduate school.
ALY688 elicits adiponectin-mimetic signaling and improves insulin action in skeletal muscle cells. Sung HK, Mitchell PL, Gross S, Marette A, Sweeney G.Am J Physiol Cell Physiol. 2022 Feb 1;322(2):C151-C163.
Identification of Circulating Endocan-1 and Ether Phospholipids as Biomarkers for Complications in Thalassemia Patients.Botta A, Forest A, Daneault C, Pantopoulos K, Tantiworawit A, Phrommintikul A, Chattipakorn S, Chattipakorn N, Des Rosiers C, Sweeney G. Metabolites. 2021 Jan 26;11(2):70.
Use of 2-dimensional cell monolayers and 3-dimensional microvascular networks on microfluidic devices shows that iron increases transendothelial adiponectin flux via inducing ROS production. Yoon N, Kim S, Sung HK, Dang TQ, Jeon JS, Sweeney G. Biochim Biophys Acta Gen Subj. 2021 Feb;1865(2):129796.
Cardiac Autophagy Deficiency Attenuates ANP Production and Disrupts Myocardial-Adipose Cross Talk, Leading to Increased Fat Accumulation and Metabolic Dysfunction.Song E, Da Eira D, Jani S, Sepa-Kishi D, Vu V, Hunter H, Lai M, Wheeler MB, Ceddia RB, Sweeney G. Diabetes. 2021 Jan;70(1):51-61.
Iron overload inhibits late stage autophagic flux leading to insulin resistance. Jahng JWS, Alsaadi RM, Palanivel R, Song E, Hipolito VEB, Sung HK, Botelho RJ, Russell RC, Sweeney G. EMBO Rep. 2019 Oct 4;20(10):e47911.
Holo-lipocalin-2-derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes.Song E, Ramos SV, Huang X, Liu Y, Botta A, Sung HK, Turnbull PC, Wheeler MB, Berger T, Wilson DJ, Perry CGR, Mak TW, Sweeney G. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1576-1581.