Professor and York Research Chair in Women’s Reproductive Health
Research areas: Molecular and Cellular Biology, Physiology, Reproduction
Dr. Peng’s primary research focuses on female reproduction and women’s reproductive health. Her lab uses a variety tools in cell and molecular biology, biochemistry, physiology, and bioinformatics to investigate how growth factors, hormones, and microRNAs regulate oocyte maturation and placental development and how their dysregulation contribute to the pathogenesis of preeclampsia. In addition, her lab studies the molecular mechanisms underlying the development of ovarian cancer.
Current research projects in Dr. Peng’s lab include: 1) MicroRNAs and Growth Factors in Placental Development and Preeclampsia; 2) Role of Cyclin G2 and MicroRNAs in Ovarian Cancer Development; and 3) Regulation of Zebrafish Ovarian Development and Oocyte Maturation. Her work is supported by CIHR, NSERC, CFI/ORF, and York University.
Salem M, O'Brien J, Bernaudo S, Shawer H, Ye G, Brkic J, Amleh A, Vanderhyden B, Reky B, Yang BB, Krylov S, and Peng C (2018). MicroRNA-590-3p promotes ovarian cancer growth and metastasis via a novel FOXA2-Versican pathway. Cancer Res 78: 4175-4190
Brkic J, Dunk C, Fu G, Nadeem L, O'Brien J, Wang YL, Rosman D, Shynlova O, Yougbaré I, Ni H, Lye S and Peng C (2018). MicroRNA-218-5p promotes endovascular trophoblast differentiation and spiral artery remodeling. Mol Ther 26: 2189-2205.
O’Brien J, Hayder H, Zayed Y, and Peng C (2018). Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol 9:402.
Hayder H, O’Brien J, Nadeem U, and Peng C (2018). MicroRNAs: Crucial regulators of placental development. Reproduction 155: R259-R271.
Yougbaré I, Tai WS, Zdravic D, Oswald BE, Lang S, Zhu G, Leong-Poi H, Qu D, Yu L, Dunk C, Zhang J, Sled JG, Lye SJ, Brkíc J, Peng C, Höglund P, Croy BA, Adamson SL, Wen XY, Stewart DJ, Freedman J, Ni H (2017). Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia. Nat Commun 8: 224. doi: 10.1038/s41467-017-00269-1.
Bernaudo S, Khazai S, Honarparvar E, Kopteva A, Peng C (2017). Epidermal growth factor promotes cyclin G2 degradation via calpain-mediated proteolysis in gynaecological cancer cells. PLoS One 12: e0179906.
Bernaudo S, Salem M, Qi X, Zhou W, Zhang C, Yang W, Rosman D, Ye G, Deng Z, Yang BB, Vanderhyden B, Wu Z, and Peng C (2016). Cyclin G2 inhibits epithelial mesenchymal transition by inhibiting β-catenin signaling. Oncogene 35: 4816-4827.
Qi X, Salem M, Zhou W, Sato Shimizu M, Ye G, Smitz J, and Peng C (2016). Neurokinin B exerts direct effects on the ovary to stimulate estradiol production. Endocrinology 157: 3355-3365.
Qi X, Zhou W, Liu Y, Li S, Ye G, Liu X, Peng C, Zhang Y, and Lin HR (2015). Goldfish Neurokinin Bs: cloning, expression, regulation, and role in reproduction. Gen Comp Endocrin 221:267-77.
Nadeem U, Ye G, Salem M, and Peng C (2014). MicroRNA-378a-5p inhibits trophoblast fusion and differentiation by targeting cyclin G2. Biol Reprod, 91:1-10.