(Core Course in Molecular and Cellular Biology)
This course will survey key concepts and important, recent developments in the field of nucleic acid biology. Fundamental processes in nucleic acid biology, including DNA and RNA synthesis, DNA recombination and repair, and mRNA processing and translation will be presented and discussed. A significant portion of the course will be devoted to recent developments highlighting the newly discovered complexity of nucleic acid biology. Potential topics include: epigenetics and DNA modification, the histone code, RNA modification and editing, RNA turnover, alternative splicing, non-coding RNA, ribozymes, riboswitches and others. The course will also cover methods currently used in nucleic acid biology. At the end of the course, students will have created and presented a graphical abstract, reviewed an individual topic with focus on unanswered questions in the field, written a grant proposal and presented a method or assay relevant to the proposal. Not all topics will be discussed each time the course is offered.
Prerequisites: Undergraduate courses in biochemistry and molecular biology.
Graphical abstract and presentation 10% (10 minutes)
Review presentation 30% (30 minutes)
Grant proposal 40% (3000-4000 words)
Method presentation 10% (10 minutes)
All materials for this course will be provided by original research and review articles in the current literature.
Nature Structural and Molecular Biology
The EMBO Journal
Genes and Development
Molecular and Cellular Biology
Nucleic Acids Research
The Journal of Biological Chemistry
The Journal of Molecular Biology
Annual Review of Genetics
Annual Review of Biochemistry