My research program is primarily concerned with elucidating mechanisms associated with the regulation of salt and water balance in aquatic animals. In this regard we place an emphasis on the endocrine system as a link between environmental change and physiological response as well as the permeability properties of occluding junctions – vertebrate tight junctions and invertebrate septate junctions.
We use model organisms that allow broad insight into the physiological and biochemical processes under study, such as aquatic arthropods, an extant agnathan (the sea lamprey), teleost fishes and amphibia. Current areas of interest include (but are not limited to) the regulation of epithelial permeability in response to environmental and systemic change, endocrine factors that regulate paracellular permeability, and the exposition and characterization of occluding junction proteins in ionoregulatory epithelia.
My goals are to gain a broader understanding of how animals "work" and to run a research program where the intellectual involvement and capacity for growth and development of trainees is front and center.
Schnell S, Stott LC, Hogstrand C, Wood CM, Kelly SP, Pärt P, Owen SF and Bury NR (2016) Procedures for the reconstruction, primary culture and experimental use of rainbow trout gill epithelia Nature Protocols (in press)
Jonusaite S, Donini A and Kelly SP (2016) Occluding junctions of invertebrate epithelia Journal of Comparative Physiology – B 186: 17-43 INVITED REVIEW
Bui P and Kelly SP (2015) Claudins in a primary cultured puffer fish (Tetraodon nigroviridis) gill epithelium model alter in response to acute seawater exposure. Comparative Biochemistry and Physiology A - Molecular & Integrative Physiology189: 91-101.
Chen CC, Kolosov D and Kelly SP (2015) Effect of liquorice root derivatives on salt and water balance in a teleost fish, rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology A - Molecular & Integrative Physiology180: 86-97.
Kolosov D, Chasiotis H and Kelly SP (2014) Tight junction protein gene expression patterns and changes in transcript abundance during development of model fish gill epithelia Journal of Experimental Biology 217: 1667-1681
Bui P and Kelly SP (2014) Claudin-6, -10d and -10e contribute to seawater acclimation in the euryhaline puffer fish Tetraodon nigroviridis Journal of Experimental Biology 217: 1758-1767
Kolosov D, Bui P, Chasiotis H and Kelly SP (2013) Claudins in teleost fishes Tissue Barriers 1:3 e25391 INVITED REVIEW
Jonusaite S, Kelly SP and Donini A (2013) Tissue specific ionomotive enzyme activity and K+ reabsorption reveal the rectum as an important ionoregulatory organ in larval Chironomus riparius exposed to varying salinity Journal of Experimental Biology 216: 3637-3648
Kolosov D and Kelly SP (2013) A role for tricellulin in the regulation of gill epithelium permeability American Journal of Physiology, Regulatory Integrative and Comparative Physiology 304: R1139-R1148
Chasiotis H, Kolosov D and Kelly SP (2012) Permeability properties of the teleost gill epithelium under ion-poor conditions American Journal of Physiology, Regulatory Integrative and Comparative Physiology 302, R727-R739
Chasiotis H, Kolosov D, Bui P and Kelly SP (2012) Tight junctions, tight junction proteins and paracellular permeability across the gill epithelium of fishes: a review Respiratory Physiology & Neurobiology 184, 269-281. INVITED REVIEW