Raymond Kwong

photo of Raymond KwongPhD (University of Saskatchewan)
Assistant Professor
E–mail: rwmkwong@yorku.ca
Website: kwong.lab.yorku.ca/
Research areas: Environmental toxicology; Molecular physiology; Neuroendocrinology; Functional genetics

Research Focus

Maintaining whole body homeostasis of ions and trace metals is fundamental to the survival of all organisms. The primary goal of our research is to develop a deeper understanding of the molecular mechanisms that underlie the homeostasis and pathophysiology of ions and trace metals in aquatic animals. We employ molecular genetics and neurophysiological technologies to investigate the endocrinology of stress, and the molecular consequences of exposure to environmental stressors, such as anthropogenic pollutants and environmental changes (i.e., change in water O2/CO2 levels). Ultimately, through our research, we aim to reduce the uncertainty in assessing the ecological impacts of contaminants, and to identify sensitive endpoints for evaluating the effects of environmental changes on aquatic health.

Representative publications:

Kwong, R.W.M., Kumai, S.F. and Perry, S.F. (2016). Neuroendocrine control of ionic balance in zebrafish. Gen. Comp. Endo., 234:40-46.

Kwong, R.W.M. and Perry, S.F. (2015). An essential role for parathyroid hormone in gill formation and differentiation of ion-transporting cells in developing zebrafish. Endocrinology, 156:2384-2394.

Kwong, R.W.M. and Perry, S.F. (2015). Hydrogen sulfide promotes calcium uptake in larval zebrafish. Am. J. Physiol. –Cell Physiol., 309:C60-69.

Kwong, R.W.M., Kumai, Y. and Perry, S.F. (2014). The physiology of fish at low pH: The zebrafish as a model system. J. Exp. Biol. 217:651-662.

Kwong, R.W.M., Auprix, D. and Perry, S.F. (2014). Involvement of the calcium-sensing receptor in calcium homeostasis in larval zebrafish exposed to low environmental calcium. Am. J. Physiol.-Reg. I. 306:R211-221.

Kwong, R.W.M. and Perry S.F. (2013). Cortisol regulates epithelial permeability and sodium losses in zebrafish exposed to acidic water. J. Endocrinol. 217:253-264.

Kwong, R.W.M. and Perry S.F. (2013). The tight junction protein claudin-b regulates epithelial permeability and sodium handling in larval zebrafish, Danio rerio. Am. J. Physiol.-Reg. I. 304: R504-513.

Kwong, R.W.M. and Niyogi, S. (2012). Cadmium transport in isolated enterocytes of freshwater rainbow trout: interactions with zinc and iron, effects of complexation with cysteine, and an ATPase-coupled efflux. Comp. Biochem. Physiol. 155C:238-246.

Kwong, R.W.M., Andrés, J. and Niyogi, S. (2011). Effects of dietary cadmium exposure on tissue-specific cadmium accumulation, iron status and expression of iron-handling and stress-inducible genes in rainbow trout: Influence of elevated dietary iron. Aquat. Toxicol. 102:1-9.

Kwong, R.W.M., Andrés, J. and Niyogi, S. (2011). Molecular evidences and physiological characterization of iron absorption in isolated enterocytes of freshwater rainbow trout (Oncorhynchus mykiss); implications for dietary cadmium and lead absorption. Aquat. Toxicol. 99: 343-350.

Kwong, R.W.M., Yu, P.K.N., Lam, P.K.S. and Wang, W.X. (2009). Biokinetics and biotransformation of DDTs in the marine green mussels Perna viridis. Aquat. Toxicol. 93, 196-204.

Kwong, R.W.M., Yu, P.K.N., Lam, P.K.S. and Wang, W.X. (2008). Uptake, elimination, and biotransformation of aqueous and dietary DDT in marine fish. Environ. Toxicol. Chem. 27, 2053-2063.

Kwong, R.W.M., Wang, W.X., Lam, P.K.S. and Yu, P.K.N. (2006). The uptake, distribution and elimination of paralytic shellfish toxins in mussels and fish exposed to toxic dinoflagellates. Aquat. Toxicol. 80, 82-91.