Jean-Paul Paluzzi

PhD (Toronto)
Assistant Professor
E–mail: paluzzi@yorku.ca
Website: www.paluzzi.lab.yorku.ca
Research areas:  Neuroendocrinology, Animal physiology, G protein-couple receptors and Neuropeptides

Research Focus

My research is focused chiefly on blood–feeding arthropods (including mosquitoes and ticks) and aims to unravel the complex neuroendocrine regulatory mechanisms that promote feeding, signal satiety, regulate growth and development of tissues involved in reproductive behaviors, and control transporting epithelia involved in the maintenance of ionic and osmotic balance. In particular, using an integrative approach combining molecular, cellular and physiological methods, my research group will examine the nature of various neurochemicals including biogenic amines and neuropeptides. Additionally, my research investigates the regulation, expression, and release of neuroendocrine factors as well as the interaction and activation with their cognate receptors and signaling partners in target cells and tissues. Importantly, since little is known on how the physiological stresses related to blood meal engorgement are detected by the nervous system, my research aims to elucidate how sensory information is centrally orchestrated to elicit a response involving these neuroendocrine regulatory systems that modulate the activity of numerous peripheral tissues (causing changes in physiology or behavior). Over the long–term, this comparative approach involving different blood-feeding arthropods will aim to elucidate how different species respond to similar challenges associated with their feeding strategy and examine if conserved neuroendocrine signaling mechanisms govern these biological processes among distantly related blood-gorging species.

Representative publications:

MacMillan, H.A., Nazal, B., Wali, S., Yerushalmi, G.Y., Misyura, L., Donini, A. and Paluzzi, J.P. (2018) Anti-diuretic activity of a CAPA neuropeptide can compromise Drosophila chill tolerance. Journal of Experimental Biology, jeb.185884.

Sajadi, F., Curcuruto, C., Al Dhaheri, A. and Paluzzi, J.P. (2018) Anti-diuretic action of a CAPA neuropeptide against a subset of diuretic hormones in the disease vector, Aedes aegypti. Journal of Experimental Biology, 221: jeb177089.

Oryan, A., Wahedi, A. and Paluzzi, J.P. (2018) Functional characterization and quantitative expression analysis of two GnRH-related peptide receptors in the mosquito, Aedes aegypti. Biochemical and Biophysical Communications, 497(2): 550-557.

Wahedi, A. and Paluzzi, J.P. (2018) Molecular identification, transcript expression, and functional deorphanization of the adipokinetic hormone/corazonin-related peptide receptor in the disease vector, Aedes aegypti. Scientific Reports, Feb 1;8(1): 2146.

Rocco, D.A., Kim, D.H. and Paluzzi, J.P. (2017) Immunohistochemical mapping and transcript expression of the GPA2/GPB5 receptor in tissues of the adult mosquito, Aedes aegypti. Cell and Tissue Research, 369 (2): 313-330.

Gondalia, K., Qudrat, A., Bruno, B. Fleites Medina, J. and Paluzzi, J.P. (2016) Identification and functional characterization of a pyrokinin neuropeptide receptor in the Lyme disease vector, Ixodes scapularis. Peptides, 86: 42-54.

Rocco, D. and Paluzzi, J.P. (2016) Functional role of the heterodimeric glycoprotein hormone, GPA2/GPB5, and its receptor, LGR1: an invertebrate perspective. General and Comparative Endocrinology, 234: 20-27.

Paluzzi, J.P., Bhatt, G. Wang, C.-H. J., Zandawala, M., Lange, A. B. and Orchard, I. (2015) Identification, functional characterization and pharmacological profile of a serotonin type-2b receptor in the medically important insect, Rhodnius prolixus. Frontiers in Neuroscience (Trends in Comparative Endocrinology and Neurobiology), 9: 175.

Paluzzi, J.P., Haddad, A.S., Sedra, L., Orchard, I. and Lange, A.B. (2015) Functional characterization and expression analysis of the myoinhibiting peptide receptor in the Chagas disease vector, Rhodnius prolixus. Molecular and Cellular Endocrinology, 399: 143-153.

Paluzzi, J.P., Vanderveken, M. and O’Donnell, M.J. (2014) The Heterodimeric Glycoprotein Hormone, GPA2/GPB5, Regulates Ion Transport across the Hindgut of the Adult Mosquito,Aedes aegypti. PLoS ONE, 9(1): e86386.

Paluzzi, J.P., Park, Y., Nachman, R.J. and Orchard, I. (2010) Isolation, expression analysis and functional characterization of the first anti–diuretic hormone receptor in insects. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 107(22): 10290–10295.