Jean-Paul Paluzzi

Jean-Paul Paluzzi headshotPhD (Toronto)
Assistant Professor
E–mail: paluzzi@yorku.ca
Website: www.yorku.ca/paluzzi/Lab/Home.html
Research areas:  Neuroendocrinology, Animal physiology, G protein-couple receptors, Hormones, Neuropeptides, Ion and water balance

Research Focus

My research is focused chiefly on blood–feeding arthropods (including mosquitoes and ticks) and aims to unravel the complex neuroendocrine regulatory mechanisms that promote feeding, signal satiety, regulate growth and development of tissues involved in reproductive behaviors, and control transporting epithelia involved in the maintenance of ionic and osmotic balance. In particular, using an integrative approach combining molecular, cellular and physiological methods, my research group will examine the nature of various neurochemicals including biogenic amines and neuropeptides. Additionally, my research investigates the regulation, expression, and release of neuroendocrine factors as well as the interaction and activation with their cognate receptors and signaling partners in target cells and tissues. Importantly, since little is known on how the physiological stresses related to blood meal engorgement are detected by the nervous system, my research aims to elucidate how sensory information is centrally orchestrated to elicit a response involving these neuroendocrine regulatory systems that modulate the activity of numerous peripheral tissues (causing changes in physiology or behavior). Over the long–term, this comparative approach involving different blood-feeding arthropods will aim to elucidate how different species respond to similar challenges associated with their feeding strategy and examine if conserved neuroendocrine signaling mechanisms govern these biological processes among distantly related blood-gorging species.

Representative publications:

Rocco, D. and Paluzzi, J.P. (2016) Functional role of the heterodimeric glycoprotein hormone, GPA2/GPB5, and its receptor, LGR1: an invertebrate perspective. General and Comparative Endocrinology, IN PRESS.

Paluzzi, J.P., Bhatt, G. Wang, C.-H. J., Zandawala, M., Lange, A. B. and Orchard, I. (2015) Identification, functional characterization and pharmacological profile of a serotonin type-2b receptor in the medically important insect, Rhodnius prolixus. Frontiers in Neuroscience (Trends in Comparative Endocrinology and Neurobiology), 9: 175.

Paluzzi, J.P., Haddad, A.S., Sedra, L., Orchard, I. and Lange, A.B. (2015) Functional characterization and expression analysis of the myoinhibiting peptide receptor in the Chagas disease vector, Rhodnius prolixus. Molecular and Cellular Endocrinology, 399: 143-153.

Paluzzi, J.P., Vanderveken, M. and O’Donnell, M.J. (2014) The Heterodimeric Glycoprotein Hormone, GPA2/GPB5, Regulates Ion Transport across the Hindgut of the Adult Mosquito,Aedes aegypti. PLoS ONE, 9(1): e86386.

Paluzzi, J.P., Yeung, C. and O’Donnell, M.J. (2013) Investigations of the signaling cascade involved in diuretic hormone stimulation of Malpighian tubule fluid secretion in Rhodnius prolixus. Journal of Insect Physiology, 59(12): 1179-1185.

Paluzzi, J.P. and O’Donnell, M.J. (2012) Identification, spatial expression analysis and functional characterization of a pyrokinin-1 receptor in the Chagas’ disease vector, Rhodnius prolixus. Molecular and Cellular Endocrinology, 363(1-2):36-45.

Paluzzi, J.P. (2012). REVIEW: Anti–diuretic factors in insects: the role of CAPA peptides. General and Comparative Endocrinology, 176(3): 300–8.

Paluzzi, J.P., Park, Y., Nachman, R.J. and Orchard, I. (2010) Isolation, expression analysis and functional characterization of the first anti–diuretic hormone receptor in insects. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 107(22): 10290–10295.