Joerg Grigull

Joerg Grigull headshotPhD (Gottingen University, Germany)
Associate Professor
E–mail: jgrigull@yorku.ca
Website: www.math.yorku.ca/~jgrigull/
Research areas: Computational Biology, mRNA Stability & Posttranscriptional Gene Regulation, Bioinformatics, Biostatistics, Genetic Epidemiology

Research Focus

Developing new methods for analysis of gene expression data and inference of regulatory DNA motifs in eukaryotic species (yeast, mouse and humans); application/ adaptation of bioinformatics methods for integration and evaluation of high-throughput data in computational projects of predicting transcription factor binding sites, evolutionary conserved protein domains, and effects of RNA secondary structure on transcript stabilities; novel methods for biomarker development based on high-throughput data (proteomics and genomics); physiological models in neuroscience.

Representative publications:

Grigull J, Mnaimneh S, Pootoolal J, Robinson MD, and Hughes TR (2004) Genome-wide analysis of mRNA stability using transcription inhibitors and microarrays reveals posttranscriptional control of ribosome biogenesis factors. Mol Cell Biol 24: 5534-47.

Zhang W, Morris QD, Chang R, Shai O, Bakowski MA, Mitsakakis N, Mohammad N, Robinson MD, Zirnglibl R, Somogyi E, Eftekharpour E, Sat E, Grigull J, Pan Q, Peng WT, Krogan N, Greenblatt J, Fehlings M, van der Kooy D, Aubin J, Bruneau BG, Rossant J, Blencowe BJ, Frey BJ, and Hughes TR (2004) The functional landscape of mouse gene expression. J Biol 3: 21.

Mnaimneh S, Davierwala AP, Haynes J, Moffat J, Peng WT, Zhang W, Yang X, Pootoolal J, Chua G, Lopez A, Trochesset M, Morse D, Krogan NJ, Hiley SL, Li Z, Morris Q, Grigull J, Mitsakakis N, Roberts CJ, Greenblatt JF, Boone C, Kaiser CA, Andrews BJ, and Hughes TR (2004) Exploration of essential gene functions via titratable promoter alleles. Cell 118: 31-44.

Krogan NJ, Peng WT, Cagney G, Robinson MD, Haw R, Zhong G, Guo X, Zhang X, Canadien V, Richards DP, Beattie BK, Lalev A, Zhang W, Davierwala AP, Mnaimneh S, Starostine A, Tikuisis AP, Grigull J, Datta N, Bray JE, Hughes TR, Emili A, Greenblatt JF (2004) High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell 13: 225-239.

Jalil S1, Grigull J1, and Skinner FK (1: co-lead authors) (2004) Novel bursting patterns emerging from inhibitory networks with synaptic depression. J Comput Neurosci 17: 31-45.

Peng, W-T, Robinson, MD, Mnaimneh S, Krogan N, Cagney G, Morris Q, Davierwala AP, Grigull J, Yang X, Zhang W, Mitsakakis N, Ryan OW, Datta N, Jojic V, Pal C, Canadien V, Richards D, Beattie B, Wu, LF, Altschuler SJ, Boone C, Roweis S, Frey BJ, Emili A, Greenblatt J, and Hughes TR (2003). A panoramic view of yeast noncoding RNA processing. Cell 113: 919-33.

Grigull J, and Skinner F (2003) The effect of synaptic depression on model inhibitory networks. Canad Appl Math Quart 10: 87-110.

Robinson M, Grigull J, Naveed M, and Hughes TR (2002) FunSpec: A web-based tool for statistical functional enrichment testing. BMC Bioinformatics 3:35.

Grigull J, Alexandrova A, and Paterson A (2001) Clustering of pedigrees using marker allele frequencies: impact on linkage analysis. Genet Epidemiol 21, Suppl S1: 61-66.

Clarke AH, Grigull J, Mueller R, and Scherer H (2000) The three-dimensional vestibuloocular reflex during prolonged microgravity. Exp Brain Res 134: 322-334.