Dorota A. Crawford

Dorota-CrawfordPhD (UBC, Vancouver)
Associate Professor in Kinesiology and Health Science and Biology
E–mail: dakc@yorku.ca
Web: www.yorku.ca/dakc
Research Areas: Genetics, Molecular/Cellular Neuroscience, Neurodevelopment

Research Focus

The major focus of my research is to identify and characterize susceptibility genes and environmental factors underlying causes of brain dysfunction in autism spectrum disorders. The emphasis is on investigating the molecular mechanisms and signaling pathways contributing to potential defects that cause abnormal brain development and lead to autism. The multidisciplinary research program in my laboratory integrates genetics, molecular and cellular neurobiology approaches to study the link between the causative biological factors and behaviour. To study protein cellular function and expression, we use in vitro and in vivo experimental systems, including neuronal and non-neuronal mammalian cell cultures and mice. We use a variety of qualitative and quantitative molecular techniques, including: cDNA subcloning, cell transfection, northern and Western blotting, immunofluorescence, immunochemistry, immunoprecipitation, cell imaging, real-time PCR, and RNA interference.