Dr. Peng’s primary research focuses on the investigating how hormones, growth factors and microRNAs regulate female reproduction and how their abnormal signaling affects women’s reproductive health. She is a leading expert in the field of ovarian cancer and in the molecular basis of complications in pregnancy. Her research has contributed to knowledge of ovarian cancer development and chemo-resistance, as well as a pregnancy-related disorder called pre-eclampsia. Current research projects in Dr. Peng’s lab include: 1) MicroRNAs and Growth Factors in Placental Development and Preeclampsia (supported by CIHR); 2) Role of Cyclin G2 and MicroRNAs in Ovarian Cancer Development (supported by CIHR); and 3) Regulation of Zebrafish Ovarian Development and Oocyte Maturation (Funded by NSERC).
Bernaudo S, Salem M, Qi X, Zhou W, Zhang C, Yang W, Rosman D, Ye G, Deng Z, Yang BB, Vanderhyden B, Zhenguo Wu and Peng C (2016). Cyclin G2 inhibits epithelial mesenchymal transition by inhibiting -Catenin signaling. Oncogene, in press.
Qi X, Zhou W, Liu Y, Li S, Ye G, Liu X, Peng C, Zhang Y, and Lin HR (2015). Goldfish Neurokinin Bs: cloning, expression, regulation, and role in reproduction. Gen Comp Endocrin 221:267-77.
Nadeem U, Ye G, Salem M, and Peng C (2014). MicroRNA-378a-5p inhibits trophoblast fusion and differentiation by targeting cyclin G2. Biol Reprod, 91:1-10.
Fu G, Ye G, Nadeem L, Ji L, Manchanda T, Wang Y, Zhao Y, Qiao J, Wang YL, Lye S Yang BB, and Peng C (2013). MicroRNA-376c is dysregulated in preeclampsia and impairs TGF- and Nodal signaling to promote trophoblast cell proliferation and invasion. Hypertension, 61:864-872.
Ji L, Brikc J, Liu, Fu G, Peng C, Wang YL (2013). Placental Trophoblast cell differentiation: physiological regulation and pathological relevance to preeclampsia. Mol Aspects Med 34:981-1023.
Nadeem L, Chen Y, Bui T, Munir S and Peng C (2013). Cytosolic mislocalization of p27 mediates the anti-migratory and anti-proliferative effects of Nodal in human trophoblast cells. J Cell Sci 126:445-453.
Luo L, Ye G, Nadeem L, Fu G, Yang BB, Honarparvar E, Dunk C, Lye S and Peng C (2012). MicroRNA 378a-5p promotes trophoblast invasion by targeting Nodal. J Cell Sci 125:3124-3132.
Fu G and Peng C (2011). Nodal Induces FoxO3a Expression and its Synergistic Interaction with Smads to Regulate Cyclin G2 Transcription and Proliferation in Ovarian Cancer Cells. Oncogene 30:3953-66.
Nadeem L, Munir S, Fu G, Dunk C, Baczyk D, Caniggia I, Lye S, Peng C (2011). Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia. Am J Pathol 178:1177-1189.
Ye G, Fu G, Cui S, Zhao S, Bernaudo S, Bai Y, Ding Y, Zhang Y, Yang BB and Peng C (2011). MicroRNA-376c enhances ovarian cancer cell survival by targeting activin receptor-like kinase 7: implication in chemoresistance. J Cell Sci, 124:359-368.