BIOL 5139 3.0 - ADVANCED EXERCISE PHYSIOLOGY I: MUSCLE

(Integrated with KAHS 6370 3.0 – host program)

Course Description:
Advanced topics in exercise physiology and biochemistry of muscle, including energy metabolism, fatigue, cell signaling and molecular adaptations to exercise and disease states.  Discussion of  original research articles in exercise physiology.

The following topics will be discussed:
The neuromuscular junction;
Excitation-contraction (E-C) coupling;
Motor unit recruitment and fiber types;
Reactive oxygen species;
Cell signaling and muscle response to contractile activity;
Energy metabolism: PCr and adenine nucleotides;
Energy metabolism: lipids and carbohydrates;
Mechanisms of muscle adaptations to chronic use and disuse;
Molecular aspects of resistance training;
Gene expression, mitochondrial biogenesis and endurance performance;
Human vs. Animal experimental models in muscle physiology;
Apoptosis in muscle;
Gene expression during recovery from exercise.

Prerequisites: York undergraduate courses Arts/Science Kinesiology 4010 3.0: Physiology of Exercise or equivalent.

Course Director:
Dr. David Hood
Kinesiology and Health Science
302 Farquharson
Tel: 416-736-2100 ext. 66640
e-mail: dhood@yorku.ca

Evaluation:
Final Exam                              40%
Paper Presentations (3)           30%
Research Paper                        30%

Bibliography:
The bibliography is up-to-date and extensive, and is available from the course director.