BIOL 5028 1.5: TOPICS IN MOLECULAR BIOLOGY II: PROTEINS

 

Course Directors:
Dr.  Yi  Sheng
327B LSB, ext. 33521

e-mail: yisheng@yorku.ca
and

Logan Donaldson
323B  LSB, ext. 22823
e-mail: logand@yorku.ca

Date and Time:  Fridays:   2:30 - 5:30
Location:  208  Calumet College
Course session:  WINTER 2018
Course ID.:  U99P01

 

 

Course Description:

This course covers the area of molecular biology called proteins, including topics in    protein synthesis, folding, transport, regulation and degradation.  Topics on proteins will include recent advances in the mechanisms and control of protein synthesis, folding, transport, regulation (allostery) and degradation.  Diseases caused by proteins such as prions and the field of protein engineering as it relates to medical, agricultural and basic research areas may also be examined. Lectures given by the course director(s) will be followed by critical class discussions of recent papers. Students are expected at the end of the course to present and oral presentation and write a critical review on topics from the above.  Not all topics will be discussed each time the course is offered. The core course will be offered as 3 hr lecture per week for 6 weeks.

Prerequisites: Undergraduate courses in biochemistry and molecular biology.

Evaluation:

Oral presentation(s)      40%
Critical review essay     40%
Class participation        20%

The oral presentation will be 30-minutes in length followed by a class discussion.  Students will also be expected to write a 3000-4000 word critical review essay on a topic of  gene expression.

Bibliography:

All materials for this course will be provided by original research and review articles in the current literature.

Journals:

Cell

Science

Nature

Genes and Development

The EMBO Journal

Proceedings of the National Academy of Sciences, USA

Molecular and Cellular Biology

The Journal of Molecular Biology

The Journal of Biological Chemistry

The Journal of Molecular Biology

Biochemistry

Annual Review of Biochemistry

Annual Review of Genetics